Often referred to as tissue transglutaminase, TG2 is a multifunctional, Ca²⁺-dependent protein that acts far beyond a simple crosslinker. It’s an enzyme that wears many hats:
When things go wrong, TG2 shifts roles. In the extracellular space, it binds to integrins and acts as a co-receptor, facilitating cell adhesion and migration. Often referred to as tissue transglutaminase, TG2 is
🔬 TG2: The Molecular "Swiss Army Knife" Shaping Cellular Fate Often referred to as tissue transglutaminase