The story follows Peter Parker, a socially awkward high school student who gains superhuman abilities after being bitten by a genetically engineered "super-spider." Following the tragic death of his Uncle Ben—which Peter could have prevented—he realizes that with great power comes great responsibility and begins fighting crime as Spider-Man. Act I: The Rise of a Hero

If you beat the game on Hero or Superhero difficulty, you unlock the ability to play through the entire story as Harry Osborn in the Green Goblin suit, featuring a completely different "alternate reality" script where Harry tries to uncover the truth about his father's death.

In the final showdown at an abandoned cathedral, Peter and Norman engage in a savage fistfight. Norman attempts to kill Peter with his remote-controlled glider, but Peter’s spider-sense allows him to dodge. The glider impales Norman instead, ending the Green Goblin's reign of terror. Peter chooses to remain a lonely hero to keep Mary Jane safe, fully embracing his destiny.

The Xbox game expands on this period by introducing , who is robbing a bank during Peter's early days. Spider-Man pursues Shocker through the city's sewer system and subway tunnels, eventually defeating him in a climactic battle at a transit station. Act II: Oscorp’s Dark Secret

Peter begins his journey by testing his new powers in an underground wrestling circuit to win money for a car. After his uncle is killed by a carjacker, Peter tracks the criminal to a warehouse, only to discover it was the same man he let escape earlier. Driven by guilt, he dedicates himself to protecting New York City.

Spider-Man (2002) for the original Xbox captures the cinematic origin of Peter Parker while expanding the film's narrative with unique comic book villains and high-stakes subplots.

The Green Goblin discovers Spider-Man’s secret identity and attacks those closest to him. He crashes a festival at Times Square, leading to a brutal aerial battle. The conflict peaks when the Goblin kidnaps Mary Jane and holds her hostage atop the Queensboro Bridge.

The game adds a major subplot involving . To gather parts for a high-tech device, Vulture terrorizes the city, leading to a massive vertical chase up a skyscraper and a battle around a clock tower. Simultaneously, Peter must contend with Oscorp’s "Hunter-Killer" robots—massive drones sent by Osborn to eliminate the "Spider-threat" interfering with his plans. Act III: The Final Confrontation