: SGK1 often acts as an oncogene , promoting tumor cell proliferation, metastasis, and resistance to therapies (e.g., Akt inhibitors) in breast, colon, and prostate cancers.
: To become fully functional, SGK1 undergoes a two-step phosphorylation process: SGK1 4 zip
: Gene variants conferring increased SGK1 activity are associated with salt-sensitive hypertension and obesity. : SGK1 often acts as an oncogene ,
SGK1 acts as a "hub" molecule regulating diverse cellular processes: promoting tumor cell proliferation