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: While PCRMP4-deficient sporozoites can still move and invade liver cells (hepatocytes) if manually extracted from oocysts, they are unable to undergo further development or proliferation within the liver. Key Characteristics

: PCRMP4 is not required for the parasite's survival during the blood-stage of infection (the stage that causes symptoms in humans), but it is absolutely necessary for completing the complex life cycle through the mosquito. Research and Medical Context pcrmp4

: The protein contains specific motifs, including Cysteine Repeat Modular (CRM) domains and EGF-like domains, which are often involved in protein-protein or host-parasite interactions. : While PCRMP4-deficient sporozoites can still move and

Plasmodium Cysteine Repeat Modular Proteins 3 and 4 are ... - NCBI pcrmp4