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: Experts at Dr. Vince Clinical Research note that the 2025 draft guidance introduces a flexible, mechanism-based framework. This allows drug developers to target shared pain pathways across multiple conditions rather than conducting duplicative trials for every specific ailment [2]. Chronic
: Organizations like SIGN are also updating their recommendations to emphasize that opioids should not be routinely prescribed for chronic pain due to insufficient evidence of long-term benefit [27, 35]. Managing Life with Chronic Pain This is for informational purposes only