Antifungal Agent Instant

: Polyene drugs act directly on the fungal cell membrane by binding to ergosterol.

: Blocking this enzyme leads to ergosterol depletion and the accumulation of toxic methylated sterols, ultimately altering membrane function and stopping growth. antifungal agent

: This binding creates physical pores or channels in the membrane. Small essential molecules and cellular organelles leak out of these pores, causing cell death. Common Examples : Amphotericin B, nystatin , and natamycin. 3. Echinocandins : Polyene drugs act directly on the fungal