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Software for motif discovery and next generation sequencing analysis



HOMER (Hypergeometric Optimization of Motif EnRichment) is a suite of tools for Motif Discovery and ChIP-Seq analysis. It is a collection of command line programs for unix-style operating systems written in mostly perl and c++. Homer was primarily written as a de novo motif discovery algorithm that is well suited for finding 8-12 bp motifs in large scale genomics data.

Hardware Requirements (recommended): 2+ Gb memory (4-8+ Gb), 10+ Gb Hard Drive space (50+ Gb)
Software Requirements: Unix compatible OS (or cygwin), perl, gcc, make, wget (optional for full functionality: R, DESeq2, blat, bedGraphToBigWig, liftOver)
License: GPLv3

HOMER works on pretty much any Linux/UNIX systems, including MacOS (if Xcode compilers are installed) and on Windows using either cygwin or a Linux subsystem.

If you are looking specifically for HOMER2, you are in the right place! HOMER2 is integrated into HOMER.

Full Program Download

56341.rar Site

Hey! I’ve uploaded the files you needed to . You’ll need WinRAR or 7-Zip to open it. It includes the [mod/save file/texture pack] we were talking about. Catch you later! To provide a more specific draft, could you clarify: What is inside the .rar file? Who is the intended audience ? Is there a password required for extraction?

Extract to the root directory and run the executable. Checksum/Verification: [Insert hash if applicable] Option 3: Casual/Gaming Context 56341.rar

Please find the archived data attached as . This folder contains the [project files/documentation/assets] we discussed earlier. Best,[Your Name] Option 2: Technical/Developer Note Update regarding 56341.rar: The latest build/patch has been compressed into 56341.rar . Contents: [Insert list, e.g., Source code, Config files] 56341.rar

Program Components and Older Versions

homer2 program - key executable for HOMER motif discovery (homerCppOnly.*.zip). (This archive actually contains all of the c++ executable, not just homer2).  Unzip in the desired directory and simply type "make" to compile the program.

The configuration script really doesn't deal with older versions, but you can download older versions yourself should you really feel like using inferior data or software!
Old Versions of HOMER Software
Old Versions of Organism Packages
Old Versions of Promoter Packages
Old Versions of Genome Packages

Update Information

Change Log - Short description of recent changes

update.txt - Current HOMER configuration list (Currently support human hg17/hg18/hg19, mouse mm8/mm9, rat rn4, X. tropicalis xenTro2, drosophila dm3, and C. elegans ce6, Zebrafish danRer7, yeast sacCer2, Arabidopsis tair10, Rice msu6, Pombe ASM294v1)


56341.rar
Can't figure something out? Questions, comments, concerns, or other feedback:
cbenner@ucsd.edu